Organoheterocyclic compounds
Number of EDCs: 145
Chemical nameChemical identifierLiterature identifier
PyrazinamideDED000019PMID:29116933
3,4-MethylenedioxymethamphetamineDED000024PMID:18309234
2-Amino-1,3,4-triazoleDED000025PMID:18779953, PMID:33892370, PMID:34757178, PMID:35385133, PMID:38685447, PMID:39134236, PMID:39414071, PMID:4177895, PMID:6868082
AmpyroneDED000030PMID:29289696
TheophyllineDED000031PMID:3371590
CaffeineDED000036PMID:23590819, PMID:3607108, PMID:36555195
CarbofuranDED000037PMID:20021136, PMID:8847449
Indole-3-carbinolDED000058PMID:12383709
IndomethacinDED000059PMID:23670170
1-Methyl-3-isobutylxanthineDED000060PMID:12127262
IsoniazidDED000062PMID:29116933
Kojic acidDED000063PMID:12533912, PMID:19483384, PMID:9734720
PatulinDED000070PMID:24995434
PhenobarbitalDED000071PMID:15150316, PMID:35385133, PMID:8661355
PhenolsulfonphthaleinDED000072PMID:17235438
PrometrynDED000075PMID:7433862
PropazineDED000077PMID:10746939, PMID:27431321
SimazineDED000080PMID:10746939, PMID:17520059, PMID:20381603, PMID:25461544
CycloheximideDED000100PMID:7662587
Ethylene oxideDED000110PMID:2815085
Vinylcyclohexene dioxideDED000161PMID:27647594, PMID:33358858, PMID:39017946
EpichlorohydrinDED000162PMID:2258022, PMID:2767356, PMID:4833816, PMID:6612740
MelamineDED000166PMID:24607646, PMID:26866683, PMID:27892862, Yin et al., 2014
TetrahydrofuranDED000168PMID:1601226, PMID:2318358
NoramidopyrineDED000200PMID:29289696
GlycidolDED000204PMID:467058
AmetrynDED000216PMID:39365753, PMID:708932
1-Methyl-2-pyrrolidinoneDED000217PMID:18468972, PMID:22311695
TestolactoneDED000221PMID:11248141
4-HydroxyazobenzeneDED000235PMID:17904329
Paraquat dichlorideDED000240PMID:4372993
ParaquatDED000241PMID:608823, PMID:8705295
MolinateDED000245PMID:9571984
2-Chloro-4,6-diamino-s-triazineDED000256PMID:15056801, PMID:24632104
Diquat dichlorideDED000257PMID:4372993
TerbuthylazineDED000262PMID:27431321
QuinalphosDED000276PMID:24581381
OrnidazoleDED000285PMID:12132656
BenomylDED000286PMID:1288759, PMID:14691014, PMID:25324206, PMID:25543211, PMID:6636195
CyanazineDED000290PMID:10647918
2-(2H-Benzotriazol-2-yl)-4,6-di-tert-pentylphenolDED000295PMID:23037998
5,7-DihydroxytryptamineDED000300PMID:6683584
ProcymidoneDED000305PMID:10188193, PMID:10188194, PMID:15013065, PMID:34902777, PMID:35913088
IprodioneDED000309PMID:17931804, PMID:34060014, PMID:37959855
1,2,3,4,7,8-HexachlorodibenzodioxinDED000318PMID:10366543
1,2,4-Trichlorodibenzo-1,4-dioxinDED000319PMID:1949037
1,2,3,7,8-Pentachlorodibenzo-p-dioxinDED000320PMID:10366543
Dibenzo(b,e)(1,4)dioxin, 2,3-dibromo-7,8-dichloro-DED000327DOI:10.1016/0045-6535(91)90040-K
2,3,7,8-Tetrabromodibenzo-4-dioxinDED000328DOI:10.1016/0045-6535(92)90467-6, PMID:17447562, PMID:8248944
2,3,4,7,8-PentachlorodibenzofuranDED000337PMID:10919282
1,2,7,8-TetrachlorodibenzofuranDED000338PMID:1332906
ParoxetineDED000343PMID:26162595, PMID:28179152
Dibenzofuran, 2,3,7,8-tetrabromo-DED000346PMID:17447562
LovastatinDED000348PMID:15884376
SimvastatinDED000349PMID:25055962, PMID:26476359, PMID:33002602
FadrozoleDED000351PMID:10630580, PMID:11248141, PMID:16962624, PMID:21959537
2-(Propan-2-yl)-9H-thioxanthen-9-oneDED000376PMID:23208609, PMID:26692070
TetramethrinDED000378PMID:16326440
FludioxonilDED000383PMID:23052036, PMID:31927052, PMID:39201710
GalaxolideDED000390PMID:23084589, PMID:37797914
TadalafilDED000411PMID:29134978
Dibenzo(b,e)(1,4)dioxin, 2-bromo-3,7,8-trichloro-DED000413DOI:10.1016/0045-6535(91)90040-K
6-methyl-1,3,8-trichlorodibenzofuranDED000414PMID:1903567
ThiaclopridDED000416PMID:28750898, PMID:38441570
2,4-Diethyl-9H-thioxanthen-9-oneDED000423PMID:23208609
4-Isopropyl-9H-thioxanthen-9-oneDED000428PMID:23208609
Oxanthrene, 2,3,7-tribromo-8-chloro-DED000432DOI:10.1016/0045-6535(91)90040-K
EtomidateDED000459PMID:18626888
2-BenzimidazolethiolDED000460PMID:10496380, PMID:33892370
Ethylene thioureaDED000463PMID:23774258
TetrahydrofurandiolDED000468PMID:17520056, PMID:18087590
N,N'-Methylene-bis(2-amino-5-sulfhydryl-1,3,4-thiadiazole)DED000475PMID:19070471
1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazoleDED000481PMID:15635152, PMID:18656497, PMID:19442818
ThiamethoxamDED000510PMID:28750898, PMID:34181816
1H-Benzimidazole, 5-methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-DED000519PMID:27002602
Omeprazole, (R)-DED000520PMID:27002602
CrizotinibDED000530PMID:23934135
FD&C Red 3DED000537PMID:20465369, PMID:2675279, PMID:2824305, PMID:824186, PMID:9061850
CylindrospermopsinDED000553PMID:18440200, PMID:35257354, PMID:36907345
Ascorbic acidDED000555PMID:23590819
SaisentongDED000561PMID:19362454
2-HydroxyatrazineDED000562PMID:24323408
Thiodiazole copperDED000567PMID:19375902
AtrazineDED000575PMID:10696778, PMID:10746939, PMID:11053540, PMID:11675267, PMID:12128101, PMID:15056801, PMID:15132767, PMID:15888671, PMID:16221967, PMID:16443249, PMID:17331471, PMID:17520059, PMID:17692527, PMID:18226067, PMID:18461179, PMID:19265281, PMID:19365547, PMID:20045047, PMID:20624442, PMID:21126571, PMID:21677308, PMID:21839517, PMID:22285353, PMID:23376530, PMID:24440342, PMID:24486430, PMID:24758756, PMID:24916741, PMID:25275270, PMID:26984284, PMID:27431321, PMID:28615648, PMID:28847621, PMID:29147981, PMID:29874772, PMID:30555326, PMID:31475654, PMID:33324343, PMID:33463082, PMID:33781367, PMID:34360708, PMID:34600026, PMID:35093817, PMID:36367780, PMID:36831314, PMID:37926918, PMID:37949145, PMID:38215996, PMID:38583534, PMID:38943029, PMID:39019188, PMID:39136868, PMID:39161789, PMID:39365753, PMID:39461294, PMID:39494159, PMID:39679284, PMID:8829248
FipronilDED000584PMID:18977275, PMID:22447239, PMID:27074097, PMID:27166213, PMID:31759041, PMID:31881178, PMID:32751827, PMID:34438272
TetrachlorodibenzodioxinDED000624PMID:10366543, PMID:10568697, PMID:10919282, PMID:11858732, PMID:11896295, PMID:12128104, PMID:12538606, PMID:12697716, PMID:14718648, PMID:15279877, PMID:15716479, PMID:15758561, PMID:15902423, PMID:16167324, PMID:16177221, PMID:16327978, PMID:17050859, PMID:17485921, PMID:17555868, PMID:18284931, PMID:19069654, PMID:19085997, PMID:19490992, PMID:19490993, PMID:19492234, PMID:19523480, PMID:19623578, PMID:19762394, PMID:19843953, PMID:19962423, PMID:20083559, PMID:20724799, PMID:20806395, PMID:20807317, PMID:20823264, PMID:20955784, PMID:21414370, PMID:21432160, PMID:21706896, PMID:22129735, PMID:22634562, PMID:23142538, PMID:23363575, PMID:23727336, PMID:25127480, PMID:25697571, PMID:26415833, PMID:27535957, PMID:27613106, PMID:28774668, PMID:29741588, PMID:29778942, PMID:30176550, PMID:30219569, PMID:31195220, PMID:31629011, PMID:32947662, PMID:33027880, PMID:34941779, PMID:35448550, PMID:36375056, PMID:37421896, PMID:38256218, PMID:7645025, PMID:9431574, PMID:9751521
CarbendazimDED000634PMID:14691014, PMID:15371226, PMID:2501910, PMID:26071454, PMID:30496565, PMID:33348257, PMID:33965443, PMID:9242589
NicotineDED000655PMID:15963341, PMID:20080174, PMID:28578073, PMID:29782138, PMID:34740714, PMID:38453095
KetoconazoleDED000666PMID:10630580, PMID:10641015, PMID:11248141, PMID:15187238, PMID:15884376, PMID:16710696, PMID:16935330, PMID:16962624, PMID:17558187, PMID:17679765, PMID:18067565, PMID:18626888, PMID:20087668, PMID:20708073, PMID:23616146, PMID:31330226, PMID:33571642, PMID:36266662, PMID:36621641, PMID:36653537, PMID:37077353, PMID:37268149, PMID:37854179, PMID:38795739, PMID:39326550
Propyl thiouracilDED000670PMID:10630580, PMID:12242606, PMID:12927363, PMID:18276755, PMID:20629314, PMID:21540284, PMID:28973696, PMID:29522169, PMID:29928935, PMID:30031104, PMID:30874585, PMID:35385133, PMID:36372265, PMID:37414127, PMID:37866749, PMID:38070162, PMID:39134236, PMID:39359896
1,2-Propylene oxideDED000696PMID:12748685, PMID:17179639, PMID:6648426
FuranDED000710PMID:31108444, PMID:31121209, PMID:32174189
CaptanDED000715PMID:29953993
FolpetDED000716PMID:29953993
CaptafolDED000725PMID:29953993
TriazophosDED000733PMID:31400790
2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)benzotriazoleDED000743PMID:17934922, PMID:18161511, PMID:27665778
TriptolideDED000752PMID:31557376
AcetamipridDED000763PMID:28395332, PMID:34855766
3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinoneDED000773PMID:31734698
PhtppDED000779PMID:29495557
Atorvastatin calcium trihydrateDED000791PMID:29574565
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDED000801PMID:39222261
6-Formylindolo(3,2-b)carbazoleDED000802PMID:32947662
AcetazolamideDED000803PMID:38580201
AlprazolamDED000804PMID:32991989
CarbamazepineDED000805PMID:37505509
DiazepamDED000808PMID:32991989
DibenzothiopheneDED000809PMID:33314207
5-FluorouracilDED000810PMID:37031830, PMID:37523981
OxazepamDED000819PMID:32991989
PentoxifyllineDED000822PMID:33984659
Mitomycin CDED000826PMID:37298413
N-NitrosomorpholineDED000828PMID:38245764
CarbazoleDED000837PMID:32344252
4-MethylimidazoleDED000866PMID:33983380
TetrahydrocannabinolDED000871PMID:37430350
DeethylatrazineDED000880PMID:39365753
Isosorbide MononitrateDED000890PMID:35648594
6-Chloro-2,3-dihydrobenzoxazol-2-oneDED000892PMID:32007685
StaurosporineDED000904PMID:35940389
FlurochloridoneDED000930PMID:33902598
3,6-DichlorocarbazoleDED000954PMID:32344252, PMID:36522090
3-BromocarbazoleDED000955PMID:32344252, PMID:36522090
RosuvastatinDED000958PMID:34345844
Metamizole SodiumDED000964PMID:35171999
CotinineDED000970PMID:38453095
MethimazoleDED000972PMID:34757178, PMID:38685447, PMID:39414071
1-Ethyl-3-methylimidazolium chlorideDED000975PMID:39019179
1-Butyl-3-methylimidazolium chlorideDED000976PMID:39019179
1-Hexyl-3-methylimidazoliumDED000977PMID:39019179
Oxine-copperDED000980PMID:36470526
Fipronil sulfoneDED000982PMID:22447239, PMID:35853389
2-(Heptafluoropropyl)-3-phenylquinoxalineDED000989PMID:35093747
TopiramateDED000995PMID:38580201, PMID:38705260
PyraclostrobinDED000997PMID:35853389, PMID:38423186, PMID:39134236
2,4,7-TrimethyldibenzothiopheneDED000998PMID:33314207
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximeDED001001PMID:39341470
2,3,7,8-Tetrachlorobenzo-p-dioxinDED001004PMID:32234510
(-)-Nicotine hydrogen (+)-tartrateDED001009PMID:35577041
2-Bromo-9H-carbazoleDED001014PMID:32344252, PMID:36522090
EnzalutamideDED001019PMID:35093747
Phenobarbital SodiumDED001026PMID:36372265, PMID:38499550, PMID:39496387
NicofluproleDED001041PMID:34922950
Difluoro{[2,2,4,5-tetrafluoro-5-(trifluoromethoxy)-1,3-dioxolan-4-yl]oxy}acetic acidDED001043PMID:37052835, PMID:38728818
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.